The tests that show which systems are at play.

by Diagnostic Solutions Laboratory

Stool qPCR panel covering pathogens, opportunistic bacteria, parasites, fungi, gut inflammation (calprotectin), barrier markers (zonulin), gut immune function (sIgA), digestive function (elastase), and antibiotic-resistance genes.

Biomarkers · Faecal calprotectin , Zonulin , Secretory IgA (stool) , Pancreatic elastase-1 (stool) , Alpha-1-antitrypsin (stool) , Akkermansia muciniphila abundance , Faecalibacterium prausnitzii abundance , Lactobacillus spp. abundance , Bifidobacterium spp. abundance , Anti-gliadin IgA , Fecal beta-glucuronidase

What results may indicate: Elevated calprotectin or zonulin can suggest barrier compromise or active inflammation; dysbiosis patterns may inform targeted gut work; pathogen identification guides eradication protocols.

by Genova Diagnostics

Comprehensive stool panel including microbiology culture + DNA, parasitology, short-chain fatty acids (SCFA), inflammation (calprotectin, sIgA), digestion (elastase), and barrier markers (alpha-1-antitrypsin).

Biomarkers · Faecal calprotectin , Secretory IgA (stool) , Pancreatic elastase-1 (stool) , Fecal acetate , Fecal butyrate , Fecal propionate , Total fecal short-chain fatty acids , Lactobacillus spp. abundance , Bifidobacterium spp. abundance , Faecalibacterium prausnitzii abundance , Alpha-1-antitrypsin (stool)

What results may indicate: Low SCFA production (acetate, butyrate) suggests fiber under-fermentation; elevated inflammation markers point to active gut immune activation.

by Doctor's Data

Stool culture + microscopy panel covering bacteria, yeast, parasites, SCFA, stool pH, digestive markers (elastase), inflammation (calprotectin), and gut immune function (sIgA).

Biomarkers · Faecal calprotectin , Pancreatic elastase-1 (stool) , Fecal acetate , Fecal butyrate , Fecal propionate , Total fecal short-chain fatty acids , Stool pH , Secretory IgA (stool) , Lactobacillus spp. abundance , Bifidobacterium spp. abundance

What results may indicate: Abnormal stool pH or low SCFA suggests fermentation imbalance; parasitology positive may indicate persistent gut infection.

by Doctor's Data

Next-generation stool panel combining qPCR + culture with microbiome diversity scoring (alpha diversity), SCFA, zonulin, calprotectin, and digestive markers.

Biomarkers · Faecal calprotectin , Zonulin , Secretory IgA (stool) , Pancreatic elastase-1 (stool) , Stool microbiome alpha-diversity , Akkermansia muciniphila abundance , Faecalibacterium prausnitzii abundance , Lactobacillus spp. abundance , Bifidobacterium spp. abundance , Firmicutes:Bacteroidetes ratio , Fecal butyrate

What results may indicate: Low microbiome diversity has been linked to atopic disease; dysbiosis ratios (firmicutes/bacteroidetes) inform fiber/prebiotic strategy.

by Gemelli Biotech

Breath test after lactulose challenge measuring hydrogen, methane, and hydrogen sulphide (H2S) — the only commercial test covering all three gases. Detects bacterial overgrowth and methanogen overgrowth (intestinal methanogen overgrowth / IMO).

Biomarkers · Hydrogen on lactulose breath test , Methane on lactulose breath test

What results may indicate: Elevated H2 with rapid rise suggests SIBO; elevated CH4 suggests IMO (often linked to constipation); elevated H2S correlates with hydrogen-sulphide-dominant patterns (often diarrhoea).

by Aerodiagnostics

Breath test after lactulose or glucose challenge measuring hydrogen and methane gas production at timed intervals. Detects bacterial overgrowth in the small intestine.

Biomarkers · Hydrogen on lactulose breath test , Methane on lactulose breath test

What results may indicate: Same H2/CH4 pattern interpretation as other SIBO breath tests; partnered with Genova Diagnostics for ordering.

by Commonwealth Diagnostics International

Lactulose or glucose breath test measuring H2 and CH4. Standard 2-gas methodology with home collection kit.

Biomarkers · Hydrogen on lactulose breath test , Methane on lactulose breath test

What results may indicate: Positive results suggest bacterial or methanogen overgrowth in the small bowel.

by Dunwoody Labs

Serum measurement of diamine oxidase (DAO), the primary enzyme responsible for breaking down dietary histamine in the gut. Low DAO is implicated in histamine intolerance.

Biomarkers · Diamine oxidase (serum) , Histamine (stool)

What results may indicate: Low DAO activity in someone with eczema, flushing, urticaria, or food-triggered symptoms supports a histamine-intolerance contribution worth dietary trial.

by Genova Diagnostics

Urine measurement after a lactulose/mannitol drink — quantifies the ratio of two sugars passing through the gut wall, the gold-standard functional assay of intestinal permeability ('leaky gut').

Biomarkers · Lactulose:mannitol ratio (urinary)

What results may indicate: Elevated lactulose recovery or L/M ratio confirms increased paracellular permeability — a more direct readout than zonulin alone.

by Genova Diagnostics

Combined blood + first-morning urine panel covering vitamins (A/D/E/B-complex), minerals (Zn, Mg, Se, Cu), amino acids, fatty acids, organic acids, oxidative stress, and antioxidant status (glutathione).

Biomarkers · Serum 25-hydroxyvitamin D , Serum zinc , Serum magnesium , Serum selenium , Serum copper , Serum folate , Serum vitamin B12 (cobalamin) , Plasma pyridoxal-5-phosphate (vitamin B6) , Plasma niacinamide / niacin (vitamin B3) , Whole-blood glutathione , Serum vitamin E (alpha-tocopherol) , Serum vitamin A (retinol) , Plasma omega-3 fatty acids (EPA + DHA)

What results may indicate: Multi-nutrient deficiencies that drive skin-barrier breakdown, immune dysregulation, or methylation impairment in eczema; prioritises supplementation strategy.

by SpectraCell Laboratories

Intracellular (lymphocyte-based) measurement of 31 vitamins, minerals, amino/fatty acids, and antioxidants — reflects long-term nutrient status rather than recent intake.

Biomarkers · Serum 25-hydroxyvitamin D , Serum zinc , Serum magnesium , Serum selenium , Serum copper , Serum folate , Serum vitamin B12 (cobalamin) , Plasma pyridoxal-5-phosphate (vitamin B6) , Plasma niacinamide / niacin (vitamin B3) , Whole-blood glutathione , Serum vitamin E (alpha-tocopherol) , Serum vitamin A (retinol)

What results may indicate: Intracellular deficiencies that serum-based panels may miss, especially for B-vitamins and glutathione.

by Vibrant Wellness

Blood panel covering vitamins (fat- and water-soluble), minerals, antioxidants, amino acids, and omega-3 fatty acids. Includes both serum and intracellular fractions for select markers.

Biomarkers · Serum 25-hydroxyvitamin D , Serum zinc , Serum magnesium , Serum selenium , Serum copper , Serum folate , Serum vitamin B12 (cobalamin) , Plasma pyridoxal-5-phosphate (vitamin B6) , Serum vitamin E (alpha-tocopherol) , Serum vitamin A (retinol) , Plasma omega-3 fatty acids (EPA + DHA)

What results may indicate: Vitamin D, zinc, or omega-3 deficiencies prevalent in atopic patients; basis for targeted supplementation.

by OmegaQuant

Dried-blood-spot finger-prick test measuring the Omega-3 Index (EPA+DHA as % of red blood cell membrane fatty acids), plus omega-6:omega-3 and AA:EPA ratios.

Biomarkers · Plasma omega-3 fatty acids (EPA + DHA)

What results may indicate: Target Omega-3 Index ≥ 8%; below 4% is associated with elevated cardiovascular and inflammatory risk and may worsen atopic inflammation.

by Genova Diagnostics

Blood panel measuring saturated, monounsaturated, and polyunsaturated fatty acids including omega-3 (EPA, DHA, ALA), omega-6 (LA, AA, GLA), and trans fats.

Biomarkers · Plasma omega-3 fatty acids (EPA + DHA)

What results may indicate: Imbalances in omega-6:omega-3 ratio (target < 4:1; Western diet often > 15:1) drive arachidonic-acid-derived inflammatory mediators relevant to eczema.

by LabCorp

Conventional plasma fatty acid panel measuring EPA, DHA, arachidonic acid (AA), and the AA:EPA ratio.

Biomarkers · Plasma omega-3 fatty acids (EPA + DHA)

What results may indicate: Standard, lab-based confirmation of omega-3 status orderable through any practitioner with a LabCorp account.

by Vibrant America

Blood panel measuring 24 fatty acids — omega-3, omega-6, omega-9, saturated, and trans — including Omega-3 Index and omega-6:omega-3 ratio.

Biomarkers · Plasma omega-3 fatty acids (EPA + DHA)

What results may indicate: Comprehensive fatty acid profile useful for dietary fat strategy planning.

by Precision Analytical

Dried urine panel collected at 4 timepoints over 24 hours — measures cortisol pattern + CAR, DHEA-S, sex hormones (estradiol, progesterone, testosterone) and their metabolites, plus melatonin.

Biomarkers · Serum cortisol , Cortisol awakening response , Dehydroepiandrosterone sulfate , Estradiol , Progesterone , Total testosterone , Melatonin

What results may indicate: Full daily cortisol pattern (often missed by single-point tests); sex hormone metabolism patterns relevant to skin and hormonal acne; melatonin status for sleep quality.

by Precision Analytical

Dried urine samples collected on 9 days across a menstrual cycle — maps estrogen and progesterone production through follicular, ovulatory, and luteal phases.

Biomarkers · Estradiol , Progesterone

What results may indicate: Cycle-phase-specific imbalances (anovulation, luteal insufficiency) that single-day tests cannot detect; relevant if eczema flares correlate with cycle phase.

by ZRT Laboratory

Saliva collected at 4 timepoints + sex hormone panel — measures diurnal cortisol pattern, DHEA-S, estradiol, progesterone, and testosterone.

Biomarkers · Serum cortisol , Cortisol awakening response , Dehydroepiandrosterone sulfate , Estradiol , Progesterone , Total testosterone

What results may indicate: Same hormonal pattern as DUTCH but using saliva; some clinicians prefer saliva for free-hormone (bioactive) measurement.

by Boston Heart Diagnostics

Serum panel including sex hormones, SHBG, DHEA-S, IGF-1, and fasting insulin — covers metabolic-hormone markers that DUTCH and ZRT under-test.

Biomarkers · Estradiol , Progesterone , Total testosterone , Sex hormone-binding globulin , Dehydroepiandrosterone sulfate , Insulin-like growth factor 1 , Fasting insulin

What results may indicate: Insulin resistance or IGF-1 patterns relevant to inflammatory skin; SHBG dynamics affecting free hormone bioavailability.

by Boston Heart Diagnostics

Comprehensive serum thyroid panel covering TSH, free T4, free T3, reverse T3, and TPO antibodies (Hashimoto's marker).

Biomarkers · Thyroid-stimulating hormone , Free thyroxine , Free triiodothyronine , Reverse triiodothyronine , Thyroid peroxidase antibodies

What results may indicate: Elevated rT3 with normal TSH suggests stress-driven thyroid down-regulation often missed in conventional screens; positive TPO indicates autoimmune thyroiditis often co-occurring with atopic conditions.

by Quest Diagnostics

Conventional lab serum panel covering TSH, free T4, free T3, reverse T3, TPO antibodies, and thyroglobulin antibodies. Available through any practitioner.

Biomarkers · Thyroid-stimulating hormone , Free thyroxine , Free triiodothyronine , Reverse triiodothyronine , Thyroid peroxidase antibodies

What results may indicate: Standard pattern interpretation: low TSH + high T4 = hyperthyroidism, etc. Inclusion of rT3 and antibodies enables a functional-medicine-grade read on conventional labs.

by ZRT Laboratory

Blood-spot (finger-prick) panel measuring TSH, free T4, free T3, reverse T3, and TPO antibodies.

Biomarkers · Thyroid-stimulating hormone , Free thyroxine , Free triiodothyronine , Reverse triiodothyronine , Thyroid peroxidase antibodies

What results may indicate: Same interpretation as serum thyroid panels with easier home collection.

by Genova Diagnostics

4-point salivary cortisol (waking, +30min, noon, evening) plus DHEA — captures the diurnal HPA pattern and cortisol:DHEA ratio.

Biomarkers · Salivary cortisol , Dehydroepiandrosterone sulfate , Cortisol:DHEA-S ratio

What results may indicate: Flat or reversed cortisol slope, low waking cortisol, or low DHEA suggest HPA-axis dysregulation from chronic stress; ratio shifts inform timing of stress-management interventions.

by BioHealth Laboratory

4-point salivary cortisol, DHEA, plus salivary secretory IgA (mucosal immune marker) — combines HPA-axis assessment with gut-immune readout.

Biomarkers · Salivary cortisol , Dehydroepiandrosterone sulfate , Secretory immunoglobulin A, salivary

What results may indicate: Low sIgA alongside cortisol pattern shifts indicates stress-induced mucosal immune suppression that can contribute to gut and skin inflammation.

by ZRT Laboratory

4-point salivary cortisol and DHEA-S with full daily curve.

Biomarkers · Salivary cortisol , Dehydroepiandrosterone sulfate , Cortisol:DHEA-S ratio

What results may indicate: Same HPA-axis interpretation as other stress panels.

by Doctor's Data

5-point salivary cortisol (extra evening sample), DHEA, and salivary sIgA.

Biomarkers · Salivary cortisol , Dehydroepiandrosterone sulfate , Secretory immunoglobulin A, salivary

What results may indicate: Extra evening sample captures late-day cortisol elevation patterns relevant to insomnia and inflammatory flares.

by LabCorp

Standard 14-marker conventional panel including liver enzymes (ALT, AST, ALP), bilirubin, albumin, kidney function, electrolytes, and glucose.

Biomarkers · Serum alanine aminotransferase (ALT) , Serum aspartate aminotransferase (AST) , Serum alkaline phosphatase (ALP) , Serum bilirubin (total) , Serum albumin

What results may indicate: Baseline liver function check — elevated ALT/AST flags hepatocellular stress; elevated ALP and bilirubin flag cholestatic patterns. Cheap and widely available.

by Genova Diagnostics

Cheek-swab DNA panel covering Phase I (CYP450 variants) and Phase II (GST, NAT, SOD, MTHFR, COMT) detoxification gene polymorphisms.

Biomarkers · MTHFR C677T variant , COMT Val158Met variant

What results may indicate: Variants in MTHFR, COMT, or Phase I/II enzymes inform personalised supplement strategy (methylfolate vs folic acid, COMT-aware estrogen handling, etc.).

by Doctor's Data

Urine panel measuring functional Phase II conjugation capacity via sulfation, glucuronidation (D-glucaric acid), and glutathione conjugation (mercapturic acids).

Biomarkers · Urinary sulfate-to-creatinine ratio , Urinary glucaric acid , Urinary mercapturic acids

What results may indicate: Low sulfate or elevated glucaric acid suggests Phase II conjugation impairment; mercapturic acid patterns reflect glutathione utilisation.

by Genova Diagnostics

Urine + optional blood spot panel covering organic acids (incl. detox markers), amino acids (methionine, cysteine, glycine for transsulfuration), oxidative stress, and methylation markers (SAM/SAH, homocysteine).

Biomarkers · Plasma homocysteine , Plasma methionine , Plasma cysteine , Plasma glycine , SAM-to-SAH ratio , Whole-blood glutathione , Urinary sulfate-to-creatinine ratio

What results may indicate: Combined view of methylation, transsulfuration, and Phase II conjugation — useful when targeting amino-acid-driven detox support (NAC, glycine, methionine).

by Mosaic Diagnostics

Urine panel measuring 70+ organic acid metabolites including detoxification markers (glucaric acid, mercapturate), oxidative stress, gut dysbiosis byproducts, and B-vitamin/CoQ10 markers.

Biomarkers · Urinary glucaric acid , Urinary mercapturic acids , Plasma homocysteine

What results may indicate: One-test view of detox + mitochondrial + gut-yeast/bacterial overgrowth markers; widely used by integrative practitioners.

by Doctor's Data

Urine (random or provoked) or hair-based measurement of toxic metals (mercury, lead, cadmium, arsenic, aluminium) and essential minerals.

What results may indicate: Elevated toxic-metal burden may contribute to oxidative stress and immune dysregulation. Hair reflects long-term exposure; urine reflects current burden.

by Quicksilver Scientific

Combined blood + hair + urine test that distinguishes organic methylmercury (from fish) from inorganic mercury (from dental amalgams or environmental) and assesses excretion capacity.

What results may indicate: High organic mercury suggests dietary fish source; high inorganic suggests amalgam or industrial source; poor excretion ratio suggests detox-pathway support need.

by Mosaic Diagnostics

Urine panel measuring 18 toxic metals — lead, mercury, cadmium, arsenic, aluminium, and others — alongside creatinine for normalisation.

What results may indicate: Elevated levels indicate ongoing exposure or impaired excretion; pair with provocation challenge if body-burden assessment is the goal.

by Mosaic Diagnostics

Urine panel measuring 11 mycotoxins from common indoor mold species (Aspergillus, Penicillium, Stachybotrys, Fusarium).

What results may indicate: Detectable mycotoxins suggest current or recent mold exposure that may drive inflammation, immune dysregulation, and skin manifestations.

by RealTime Laboratories

Urine ELISA panel measuring 15 mycotoxins; longer-established methodology than newer competitors and uses non-provoked collection.

What results may indicate: Positive mycotoxins indicate body burden from mold exposure.

by Vibrant America

Urine panel covering mycotoxins from Aspergillus, Penicillium, Stachybotrys, and Fusarium species using LC-MS/MS.

What results may indicate: Same mycotoxin burden interpretation as MycoTOX with comparable methodology.

by Mycometrics

DNA-based qPCR analysis of dust samples from your home, quantifying 36 mold species against EPA water-damage reference indices.

What results may indicate: Elevated ERMI score suggests significant indoor mold contamination that may drive symptoms; useful for source identification before remediation.

by RealTime Laboratories

Dust sample analysis combining mold species identification (qPCR) with mycotoxin quantification (ELISA) — measures both organisms and their toxins in the home.

What results may indicate: Identifies the specific mold species producing mycotoxins indoors; useful for targeted remediation strategy.

by Vibrant America

Blood panel measuring IgE and IgG/IgG4 reactivity against 200+ environmental and food antigens.

Biomarkers · Total immunoglobulin E (IgE) , Allergen-specific IgE panel

What results may indicate: Identifies specific allergen sensitivities (foods, pollens, molds) that may be triggering atopic flares; informs elimination-trial strategy.

by US BioTek

Blood panel measuring IgE, IgG, IgG4, and complement reactivity against 96-208 food antigens depending on panel.

Biomarkers · Total immunoglobulin E (IgE) , Allergen-specific IgE panel

What results may indicate: Same elimination-trial guidance as Vibrant; complement-based reactivity may add specificity over IgG-only.

by LabCorp

Standard CBC with differential (white blood cell types including eosinophils) plus high-sensitivity CRP for systemic inflammation.

Biomarkers · Eosinophil count , High-sensitivity C-reactive protein (hs-CRP)

What results may indicate: Elevated eosinophils support atopic/allergic immune skewing; elevated hsCRP signals systemic inflammation regardless of cause. Cheap and widely available.

by Mosaic Diagnostics

Urine panel measuring 70+ organic acid metabolites including Krebs cycle intermediates (succinate, alpha-KG, citrate), B-vitamin sufficiency markers (MMA for B12, FIGLU for folate), oxidative stress (8-OHdG), and gut microbial metabolites.

Biomarkers · Succinate (urine organic acid) , Alpha-ketoglutarate (urine organic acid) , Citrate (urine organic acid) , Methylmalonic acid (MMA) , 8-hydroxy-2-deoxyguanosine (8-OHdG) , Thiamine (vitamin B1) , Riboflavin (vitamin B2)

What results may indicate: Elevated Krebs intermediates signal mitochondrial bottlenecks; elevated MMA suggests B12 insufficiency at the cellular level; 8-OHdG flags oxidative DNA damage.

by Genova Diagnostics

Urine panel covering 46 organic acids reflecting carbohydrate metabolism, energy production, fatty acid oxidation, neurotransmitter metabolism, and detoxification.

Biomarkers · Succinate (urine organic acid) , Alpha-ketoglutarate (urine organic acid) , Citrate (urine organic acid) , Methylmalonic acid (MMA) , Thiamine (vitamin B1) , Riboflavin (vitamin B2)

What results may indicate: Genova's interpretive reporting maps results to nutrient cofactor needs (B-vitamins, magnesium, CoQ10) and recommends targeted supplementation.